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Detection of Preclinical Parkinson Disease in At-Risk Family Members With Use of [123I]-CIT and SPECT: An Exploratory Study

Identifieur interne : 001D00 ( Main/Exploration ); précédent : 001C99; suivant : 001D01

Detection of Preclinical Parkinson Disease in At-Risk Family Members With Use of [123I]-CIT and SPECT: An Exploratory Study

Auteurs : Demetrius M. Maraganore ; Michael K. O'Connor ; James H. Bower ; Karen M. Kuntz ; Shannon K. Mcdonnell ; Daniel J. Schaid ; Walter A. Rocca

Source :

Mayo Clinic Proceedings [ 0025-6196 ] ; 1999.

RBID : ISTEX:25158DAE2140C6BF84D91F8DAB5BC726D7E0D3DF

Abstract

Objective To explore whether the radiloligand 2carboxymethoxy-3-(4-P23I] iodophenyl) tropane ([1,231]-CIT) and single-photon emission computed tomography (SPECT) can detect decreased striatal uptake in at-risk relatives of patients with Parkinson disease (PD).Patients and Methods Ten PD patients, 10 at-risk first-degree relatives of PD patients, and 10 controls underwent [1231] CIT and SPECT brain imaging. Their striatal uptake ratios were compared.Results Age-adjusted specific to nonspecific striatal uptake ratios were lower in patients compared with controls and with relatives; however, ratios were similar in relatives and controls. Among relatives, ratios were consistently lower in subgroups postulated to be at higher risk for preclinical PD.Conclusion Our findings provide preliminary support that [1231]-CIT and SPECT may detect decreased striatal uptake in relatives of PD patients postulated to be at higher risk for PD.

Url:

https://api.istex.fr/document/25158DAE2140C6BF84D91F8DAB5BC726D7E0D3DF/fulltext/pdf

DOI: 10.4065/74.7.681

Affiliations:

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<author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name>
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<author><name sortKey="O Connor, Michael K" sort="O Connor, Michael K" uniqKey="O Connor M" first="Michael K." last="O'Connor">Michael K. O'Connor</name>
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<author><name sortKey="Bower, James H" sort="Bower, James H" uniqKey="Bower J" first="James H." last="Bower">James H. Bower</name>
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<author><name sortKey="Kuntz, Karen M" sort="Kuntz, Karen M" uniqKey="Kuntz K" first="Karen M." last="Kuntz">Karen M. Kuntz</name>
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<author><name sortKey="Mcdonnell, Shannon K" sort="Mcdonnell, Shannon K" uniqKey="Mcdonnell S" first="Shannon K." last="Mcdonnell">Shannon K. Mcdonnell</name>
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<author><name sortKey="Schaid, Daniel J" sort="Schaid, Daniel J" uniqKey="Schaid D" first="Daniel J." last="Schaid">Daniel J. Schaid</name>
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<author><name sortKey="Bower, James H" sort="Bower, James H" uniqKey="Bower J" first="James H." last="Bower">James H. Bower</name>
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<series><title level="j">Mayo Clinic Proceedings</title>
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<front><div type="abstract">Objective To explore whether the radiloligand 2carboxymethoxy-3-(4-P23I] iodophenyl) tropane ([1,231]-CIT) and single-photon emission computed tomography (SPECT) can detect decreased striatal uptake in at-risk relatives of patients with Parkinson disease (PD).Patients and Methods Ten PD patients, 10 at-risk first-degree relatives of PD patients, and 10 controls underwent [1231] CIT and SPECT brain imaging. Their striatal uptake ratios were compared.Results Age-adjusted specific to nonspecific striatal uptake ratios were lower in patients compared with controls and with relatives; however, ratios were similar in relatives and controls. Among relatives, ratios were consistently lower in subgroups postulated to be at higher risk for preclinical PD.Conclusion Our findings provide preliminary support that [1231]-CIT and SPECT may detect decreased striatal uptake in relatives of PD patients postulated to be at higher risk for PD.</div>
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<name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name>
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<name sortKey="Schaid, Daniel J" sort="Schaid, Daniel J" uniqKey="Schaid D" first="Daniel J." last="Schaid">Daniel J. Schaid</name>
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Detection of Preclinical Parkinson Disease in At-Risk Family Members With Use of [123I]-CIT and SPECT: An Exploratory Study

Detection of Preclinical Parkinson Disease in At-Risk Family Members With Use of [123I]-CIT and SPECT: An Exploratory Study

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Abstract

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